@article {Nguyen2021aa,
	title = {Rheological basis of skeletal muscle work loops},
	journal = {ArXiv e-prints},
	volume = {arXiv:2005.07238 [cond-mat.soft]},
	number = {arXiv:2005.07238 [cond-mat.soft]},
	year = {2021},
	abstract = {<p>Skeletal muscle is subjected to simultaneous time-varying neural stimuli and length changes in vivo. Work loops are experimental representations of these in vivo conditions and exhibit force versus length responses that are not explainable using either soft matter rheology or the classical isometric and isotonic characterizations of muscle. These gaps in our understanding have often prompted the search for new muscle phenomena. However, we presently lack a framework to explain the mechanical origins of work loops that integrates multiple facets of current understanding of muscle, as a rheological material and also a stimulus-responsive actuator. Here we present a new hypothesis that work loops emerge by splicing together force versus length loops corresponding to different constant stimuli. Using published muscle datasets and a detailed sarcomere model, we find that the hypothesis accurately predicts work loops and helps understand them in terms of rheological behaviors measured at fixed-stimuli. Importantly, this framework identifies conditions under which a rheological understanding of muscle fails to explain the emergent work loops, and new muscle phenomena may be necessary to explain its in vivo function.</p>
},
	author = {Khoi D. Nguyen and Madhusudhan Venkadesan}
}
